反应详情

Following the procedure of Example 5, a mixture of 1-(2-hydroxyphenyl)piperazine dihydrobromide (9.6 g, 0.0282 mol), 5-(3-chloropropyl)-3-methyl-2-oxazolidinone (5.0 g, 0.0282 mol), sodium bicarbonate (9.5 g, 0.113 mol), and potassium iodide in 1-butanol (100 ml) gave an oil. The oil was triturated several times with light pet ether (decanting each time) and dissolved in ethyl acetate/isopropyl ether. Cooling the solution gave a solid which was collected by filtration and dried under high vacuum to give 1.80 g (20% yield), mp 112°-116° C.

1. customgave an oil
2. customThe oil was triturated several times with light pet ether (
3. customdecanting each time) and
4. dissolutiondissolved in ethyl acetate/isopropyl ether
5. temperatureCooling the solution
6. customgave a solid which
7. filtrationwas collected by filtration
8. customdried under high vacuum
9. customto give 1.80 g (20% yield), mp 112°-116° C.