反应详情

Following the procedure of Example 5, a mixture of 5-(4-chlorobutyl)-3-phenyl-2-oxazolidinone (3.0 g, 0.01186 mol), 1-(2-pyrimidinyl)piperazine dihydrochloride (2.81 g, 0.01186 mol), potassium carbonate (9.85 g, 0.0713 mol), and potassium iodide (1.0 g) in n-butanol (75 mL) gave a solid (4.1 g, 91% yield). The solid was recrystallized from isopropanol/isopropyl ether and dried under high vacuum to give 2.58 g, mp 94°-96° C.