Hydrochloric Acid → HCID 19811344, compound

HRID 373056Notes

Reaction equation

HRID 373056 reaction equation
[Br:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]([CH2:10][CH2:11][N:12]([CH3:14])[CH3:13])[C:7](=[O:9])[NH:8][C:4]=2[CH:3]=1.[ClH:17]>C(O)C.C(OCC)C.O1CCOCC1>[ClH:17].[Br:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]([CH2:10][CH2:11][N:12]([CH3:13])[CH3:14])[C:7](=[O:9])[NH:8][C:4]=2[CH:3]=1

Participants

6

Reactant 2

HCID 313Hydrochloric AcidHCID 19811321HCID 19811321, compound

Product 1

HCID 19811344HCID 19811344, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 5-bromo-1,3-dihydro-1-(2-dimethylaminoethyl)-2H-benzimidazol-2-one (510 mg) in ethanol (5 ml) and diethyl ether (50 ml) was added 4N hydrogen chloride in dioxane dropwise with stirring. The separated crystals were collected by suction and dried to give 490 mg of 5-bromo-1,3-dihydro-1-(2-dimethylaminoethyl)-2H-benzimidazol-2-one hydrochloride.

Workup

  1. customThe separated crystals were collected by suction
  2. customdried

Sources & evidence

ORD record
ord-dd435a4f46684108800c8b01a7ad2e7a
Source dataset
uspto-grants-1992_11
Patent number
US05162318

Reaction notes

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