Hydrochloric Acid → 1,3-dihydro-1-(2-dimethylaminoethyl)-2H-benzimidazol-2-one hydrochloride

HRID 373069Notes

Reaction equation

HRID 373069 reaction equation
[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[NH:7][C:6]1=[O:14].[ClH:16]>CCOCC.O1CCOCC1>[ClH:16].[CH3:1][N:2]([CH3:15])[CH2:3][CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[NH:7][C:6]1=[O:14]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 148946781-[2-(Dimethylamino)ethyl]-1,3-dihydrobenzimidazol-2-one

Product 1

HCID 198113961,3-dihydro-1-(2-dimethylaminoethyl)-2H-benzimidazol-2-one hydrochloride

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 1,3-dihydro-1-(2-dimethylaminoethyl)-2H-benzimidazol-2-one (1.32 g) in ether (40 ml) was added 4N hydrogen chloride in dioxane dropwise with stirring. The separated crystals were collected by suction and dried to give 930 mg of 1,3-dihydro-1-(2-dimethylaminoethyl)-2H-benzimidazol-2-one hydrochloride.

Workup

  1. customThe separated crystals were collected by suction
  2. customdried

Sources & evidence

ORD record
ord-2cf0524c150345ce9ff7b94e3819d355
Source dataset
uspto-grants-1992_11
Patent number
US05162318

Reaction notes

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