Acetic Anhydride → N-(4-cyanophenyl)acetamide

HRID 373072Notes

Reaction equation

HRID 373072 reaction equation
[NH2:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.[C:10](OC(=O)C)(=[O:12])[CH3:11]>O>[C:10]([NH:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1)(=[O:12])[CH3:11]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 133964-Aminobenzonitrile

Product 1

HCID 37256N-(4-cyanophenyl)acetamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 4-aminobenzonitrile (7.26 g) was added acetic anhydride (20 ml) and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was diluted with water and the separated crystals were collected by suction, washed with water and dried under reduced pressure to give 9.40 g of 4-acetamidobenzonitrile.

Workup

  1. customthe separated crystals were collected by suction
  2. washwashed with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-fde8b7c4aff840878098695651e8da1b
Source dataset
uspto-grants-1992_11
Patent number
US05162318

Reaction notes

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