反应详情

To a solution of 2.20 g of 4-amino-3-nitrobenzophenone and 1.57 g of 4-methoxybenzyl chloride in 25 ml of N,N-dimethylformamide was added at room temperature 0.40 g of 60% dispersion of sodium hydride in mineral oil, and the mixture was stirred overnight. After addition of saturated ammonium chloride aqueous solution was completed, the reaction mixture diluted with ethyl acetate was washed with brine. Removal of the solvent under reduced pressure gave the crude product, which was chromatographed on silica gel. Elution with hexane-ethyl acetate (3:1) provided 1.95 g of 4-(4-methoxybenzylamino)-3-nitrobenzophenone.

1. washwas washed with brine
2. customRemoval of the solvent under reduced pressure
3. customgave the crude product, which
4. customwas chromatographed on silica gel
5. washElution with hexane-ethyl acetate (3:1)