反应详情

温度

0 °C

To a solution 1.8394 g of N-[3-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-4(2-thienyl)-2-pyrimidinamine in 25 ml of hot ethyl alcohol is added ml of 3.58N HCl in ethyl alcohol. The solution turns yellow and begins to boil. The reaction mixture is cooled to 0° C., the crystals collected, washed with 1 ml of ethyl alcohol, followed by ether. The yellow crystals are collected and vacuum dried to afford 1.87 g, mp 233°-237° C.

1. customthe crystals collected
2. washwashed with 1 ml of ethyl alcohol
3. customThe yellow crystals are collected
4. customvacuum dried
5. customto afford 1.87 g, mp 233°-237° C.