Hydrochloric Acid → N-[3-[2-(1H-Imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine hydrochloride

HRID 373079Notes

Reaction equation

[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[C:11]([NH:15][C:16]3[N:21]=[C:20]([C:22]4[S:23][CH:24]=[CH:25][CH:26]=4)[CH:19]=[CH:18][N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[ClH:27]>C(O)C>[ClH:27].[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[C:11]([NH:15][C:16]3[N:21]=[C:20]([C:22]4[S:23][CH:24]=[CH:25][CH:26]=4)[CH:19]=[CH:18][N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

Conditions

Temperature: 0 °C

Procedure

To a solution 1.8394 g of N-[3-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-4(2-thienyl)-2-pyrimidinamine in 25 ml of hot ethyl alcohol is added ml of 3.58N HCl in ethyl alcohol. The solution turns yellow and begins to boil. The reaction mixture is cooled to 0° C., the crystals collected, washed with 1 ml of ethyl alcohol, followed by ether. The yellow crystals are collected and vacuum dried to afford 1.87 g, mp 233°-237° C.

Workup

customthe crystals collected
washwashed with 1 ml of ethyl alcohol
customThe yellow crystals are collected
customvacuum dried
customto afford 1.87 g, mp 233°-237° C.

Sources & evidence

ORD record: ord-1b15673024094bb59d9b2c7cf78bfc33
Source dataset: uspto-grants-1992_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05162328

Reaction notes

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