Malic Acid → HCID 19811573, compound

HRID 373085Notes

Reaction equation

HRID 373085 reaction equation
[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[C:11]([NH:15][C:16]3[N:21]=[C:20]([C:22]4[S:23][CH:24]=[CH:25][CH:26]=4)[CH:19]=[CH:18][N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.[C:27]([OH:35])(=[O:34])[CH:28]([CH2:30][C:31]([OH:33])=[O:32])[OH:29]>C(O)C>[OH:29][CH:28]([CH2:30][C:31]([OH:33])=[O:32])[C:27]([OH:35])=[O:34].[N:1]1([CH2:6][CH2:7][O:8][C:9]2[CH:10]=[C:11]([NH:15][C:16]3[N:21]=[C:20]([C:22]4[S:23][CH:24]=[CH:25][CH:26]=4)[CH:19]=[CH:18][N:17]=3)[CH:12]=[CH:13][CH:14]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Participants

4

Reactant 2

HCID 525Malic AcidHCID 9820417N-[3-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine

Product 1

HCID 19811573HCID 19811573, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of 1.0 g of N-[3-[2-(1H- imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine in 10 ml of hot ethyl alcohol is added 5 ml of ethyl alcohol containing 0.37 g of malic acid. Crystals begin to form and the reaction mixture is cooled. The solid is collected by filtration, washed with ethyl alcohol and dried to afford the desired product.

Workup

  1. customto form
  2. temperaturethe reaction mixture is cooled
  3. filtrationThe solid is collected by filtration
  4. washwashed with ethyl alcohol
  5. customdried

Sources & evidence

ORD record
ord-945f90ea6da745e0a4dd50ae865c0771
Source dataset
uspto-grants-1992_11
Patent number
US05162328

Reaction notes

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