Methanol → HCID 19811579, compound

HRID 373101Notes

Reaction equation

HRID 373101 reaction equation
C(C1[C:10]([C:11](=[CH2:14])[CH:12]=[O:13])=[CH:9][CH:8]=[CH:7]N=1)CCC.C[N:16]1[CH2:21][CH2:20]O[CH2:18][CH2:17]1.[H][H].[CH3:24]O>>[N:16]1[CH:17]=[CH:18][CH:24]=[C:20]([CH2:14][CH:11]([CH2:10][CH2:9][CH2:8][CH3:7])[CH2:12][OH:13])[CH:21]=1

Participants

5

Reactant 4

HCID 887MethanolHCID 79724-MethylmorpholineHCID 86746311HCID 86746311, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19811579HCID 19811579, compound

Procedure

A mixture of 21 g (0.11 mol) of 2-butyl-3-pyridylpropenal, 120 ml of methanol, 10 g of N-methylmorpholine and 6 g of a hydrogenation catalyst (10% of Pd and 5% of Pr2O3 on Al2O3) is hydrogenated at 75° C. and 75 bar hydrogen pressure in a 0.3 1 stirred autoclave until the pressure remains constant. The solution is filtered under suction over silica gel, the filtrate is evaporated down under reduced pressure and the residue is purified by distillation.

Workup

  1. customis hydrogenated at 75° C.
  2. filtrationThe solution is filtered under suction over silica gel
  3. customthe filtrate is evaporated down under reduced pressure
  4. distillationthe residue is purified by distillation

Sources & evidence

ORD record
ord-2e41f86c6c3d4858948f8c68b776c858
Source dataset
uspto-grants-1992_11
Patent number
US05162329

Reaction notes

Loading…