1,3-Dimethyl-5-ethoxycarbonylbarbituric acid → HCID 19811558, compound

HRID 373105Notes

Reaction equation

HRID 373105 reaction equation
[F:1][C:2]([F:23])([O:9][CH:10]([F:22])[C:11]([F:21])([F:20])[O:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][CH:14]=1)[C:3]([F:8])([F:7])[CH:4]([F:6])[F:5].[CH3:24][N:25]1[C:32](=[O:33])[CH:31]([C:34](OCC)=[O:35])[C:29](=[O:30])[N:28]([CH3:39])[C:26]1=[O:27]>C1(C)C=CC=CC=1>[CH3:39][N:28]1[C:29](=[O:30])[CH:31]([C:34](=[O:35])[NH:17][C:16]2[CH:18]=[CH:19][C:13]([O:12][C:11]([F:21])([F:20])[CH:10]([O:9][C:2]([F:23])([F:1])[C:3]([F:7])([F:8])[CH:4]([F:5])[F:6])[F:22])=[CH:14][CH:15]=2)[C:32](=[O:33])[N:25]([CH3:24])[C:26]1=[O:27]

Participants

4

Reactant 2

HCID 5937141,3-Dimethyl-5-ethoxycarbonylbarbituric acidHCID 14819451HCID 14819451, compound

Product 1

HCID 19811558HCID 19811558, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

14.50 g (40.6 mmol) of 4-(2-(1,1,2,2,3,3-hexafluoropropoxy)-1,1,2-trifluoroethoxy)-aniline were added to 9.26 g (40.6 mmol) of 1,3-dimethyl-5-ethoxycarbonylbarbituric acid in 100 ml of toluene, the mixture was stired under reflux for 2.5 hours and concentrated and the residue was recrystallized from methanol.

Workup

  1. temperatureunder reflux for 2.5 hours
  2. concentrationconcentrated
  3. customthe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-df7e9aa50fd54996b8f60d7cfc04b264
Source dataset
uspto-grants-1992_11
Patent number
US05162327

Reaction notes

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