Azido(trimethyl)stannane → HCID 178441453, compound

HRID 373130Notes

Reaction equation

HRID 373130 reaction equation
[CH2:1]([C:5]1[N:14]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]3[C:23]([C:28]#[N:29])=[N:24][CH:25]=[CH:26][CH:27]=3)=[CH:18][CH:17]=2)[C:13](=[O:30])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH3:31])[CH:11]=2)[N:6]=1)[CH2:2][CH2:3][CH3:4].C[Sn]([N:36]=[N+:37]=[N-:38])(C)C>C1(C)C=CC=CC=1>[CH2:1]([C:5]1[N:14]([CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]3[C:23]([C:28]4[NH:38][N:37]=[N:36][N:29]=4)=[N:24][CH:25]=[CH:26][CH:27]=3)=[CH:18][CH:17]=2)[C:13](=[O:30])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([CH3:31])[CH:11]=2)[N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

4

Reactant 2

HCID 5104973Azido(trimethyl)stannaneHCID 198115132-Butyl-6-methyl-3-[[4-(2-cyanopyridin-3-yl)phenyl]methyl]quinazolin-4(3H)-one

Product 1

HCID 178441453HCID 178441453, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of the product of step C (1.0 eq.) is added trimethylstannylazide (3 eq.) in toluene (3 mL) and heated to reflux for 36 h. The mixture is cooled to rt, concentrated and then can be purified by flash chromatography on SiO2 to give the titled compound.

Workup

  1. temperatureheated
  2. temperatureto reflux for 36 h
  3. concentrationconcentrated
  4. customcan be purified by flash chromatography on SiO2

Sources & evidence

ORD record
ord-880b91e67ef84260867a78725a778a89
Source dataset
uspto-grants-1992_11
Patent number
US05162325

Reaction notes

Loading…