Dimethylformamide → HCID 19811955, compound

HRID 373144Notes

Reaction equation

HRID 373144 reaction equation
[SH:1][C:2]1[O:3][C:4]([C:7]2[O:11][C:10]([N:12]([CH3:14])[CH3:13])=[N:9][N:8]=2)=[N:5][N:6]=1.O1CCOCC1.CN(C)C=O.Br[CH2:27][CH2:28][C:29]([F:33])=[C:30]([F:32])[F:31]>O>[F:33][C:29](=[C:30]([F:32])[F:31])[CH2:28][CH2:27][S:1][C:2]1[O:3][C:4]([C:7]2[O:11][C:10]([N:12]([CH3:14])[CH3:13])=[N:9][N:8]=2)=[N:5][N:6]=1

Participants

6

Reactant 4

HCID 6228DimethylformamideHCID 312751,4-DioxaneHCID 663334-Bromo-1,1,2-trifluorobut-1-eneHCID 178483107HCID 178483107, compound

Product 1

HCID 19811955HCID 19811955, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

4.26 g of 2-mercapto-5-(2-dimethylamino-1,3,4-oxadiazol-5-yl)-1,3,4-oxadiazole according to Example H2 are initially introduced into 40 ml of dioxane and stirred with 2.24 g of potassium t-butylate. 4 ml of dimethylformamide and then 4.2 g of 4-bromo-1,1,2-trifluorobut-1-ene are added and the mixture is stirred overnight at room temperature. The mixture is poured into water and the crystals are filtered off with suction. After drying and stirring with ether, 4.6 g of the title compound of melting point 87°-90° C. are obtained.

Workup

  1. filtrationthe crystals are filtered off with suction
  2. customAfter drying
  3. stirringstirring with ether, 4.6 g of the title compound of melting point 87°-90° C.
  4. customare obtained

Sources & evidence

ORD record
ord-cb0458332f62444597fd8cc0e25ef86f
Source dataset
uspto-grants-1992_11
Patent number
US05162349

Reaction notes

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