反应详情

0.5 ml of glacial acetic acid was added to a solution of 10.0 g (84.0 mmol) of 6-methyl-2-vinylpyridine and 10.2 g (84 mmol) of N-methylbenzylamine in 100 ml of a mixture of methanol with water (1:1) and the mixture thus obtained was refluxed for 8 h. The mixture was concentrated and the residue was purified by silica gel column chromatography (chloroform/methanol/aqueous ammonia=97:3:0.3). A fraction containing the intended compound was concentrated to give the compound in the form of an oil.

1. customthe mixture thus obtained
2. temperaturewas refluxed for 8 h
3. concentrationThe mixture was concentrated
4. customthe residue was purified by silica gel column chromatography (chloroform/methanol/aqueous ammonia=97:3:0.3)
5. additionA fraction containing the intended compound
6. concentrationwas concentrated
7. customto give the compound in the form of an oil