反应详情

A mixture of 5.0 g of 2,6-bis(1,1-dimethylethyl)-4-mercaptophenol, 4.0 ml of acrolein, 0.5 ml of triethylamine, and 60 ml of methanol was stirred at room temperature for 17 hr. Then the mixture was distilled to dryness under reduced pressure. The residual oil was chromatographed on silica gel. The column was eluted with hexane-ethyl acetate to furnish 3-[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]thio]propanal as viscous oil.

1. distillationThen the mixture was distilled to dryness under reduced pressure
2. customThe residual oil was chromatographed on silica gel
3. washThe column was eluted with hexane-ethyl acetate