反应详情

温度

100 °C

A solution of 23 g of ethyl dodecanoate and 62.7 g of ethylenediamine in 100 ml of tetrahydrofuran (THF) was refluxed for 3 hours and the excess THF was distilled off. The reaction mixture was heated at 100° C. for 16 hours, cooled to room temperature, poured into cold water and extracted with ether. After drying, the organic solution was concentrated to give 15.7 g of crude product and this was recrystallized from ether-hexane to give 10.9 g of pure product, m.p. 64°-66° C.

1. distillationthe excess THF was distilled off
2. temperaturecooled to room temperature
3. additionpoured into cold water
4. extractionextracted with ether
5. customAfter drying
6. concentrationthe organic solution was concentrated
7. customto give 15.7 g of crude product
8. customthis was recrystallized from ether-hexane