反应详情

A mixture of 6-chloro-1-(2'-cyanobiphenyl-4-yl)methyl-3-propylpyrimidine-2,4(1H,3H)-dione (0.7 g), propylmercaptan (0.2 ml) and potassium carbonate (0.51 g) in acetonitrile (12 ml) was stirred at room temperature for 3 hours. The reaction mixture was concentrated to dryness and then the residue was extracted with methylene chloride-water. The organic layer was washed with water, dried, and evaporated to dryness to give colorless syrups (0.77 g, 100%).

1. concentrationThe reaction mixture was concentrated to dryness
2. extractionthe residue was extracted with methylene chloride-water
3. washThe organic layer was washed with water
4. customdried
5. customevaporated to dryness