3-Amino-1-propanol → HCID 178509483, compound

HRID 373313Notes

Reaction equation

HRID 373313 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][C:5]([C:10]2[CH:15]=[CH:14][N+:13]([O-:16])=[CH:12][CH:11]=2)=[CH:4][N:3]=1.[NH2:17][CH2:18][CH2:19][CH2:20][OH:21]>>[OH2:16].[C:8]([C:7]1[C:2]([NH:17][CH2:18][CH2:19][CH2:20][OH:21])=[N:3][CH:4]=[C:5]([C:10]2[CH:15]=[CH:14][N+:13]([O-:16])=[CH:12][CH:11]=2)[CH:6]=1)#[N:9]

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 10243008HCID 10243008, compound

Product 1

HCID 178509483HCID 178509483, compound

Procedure

The procedure of Example 7 is followed to react and work up 5 g 2-chloro-3-cyano-5,4'-bipyridine-1'-oxide and 8 ml 3-amino-propan-1-ol. The product is recrystallized from ethanol/water. Yield: 4.87 g (78.4% of the theoretical yield), with a melting point of 141° C.-143° C.

Workup

  1. customto react
  2. customThe product is recrystallized from ethanol/water
  3. customYield: 4.87 g (78.4% of the theoretical yield), with a melting point of 141° C.-143° C.

Sources & evidence

ORD record
ord-531f9acbc8f74dafa4e19dc635cca398
Source dataset
uspto-grants-1992_11
Patent number
US05162533

Reaction notes

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