Glycerol → HCID 19812355, compound

HRID 373316Notes

Reaction equation

HRID 373316 reaction equation
[OH-].[K+].Cl[C:4]1[C:9]([C:10]#[N:11])=[CH:8][C:7]([C:12]2[CH:17]=[CH:16][N+:15]([O-:18])=[CH:14][CH:13]=2)=[CH:6][N:5]=1.O.[OH:20][CH2:21][CH:22]([CH2:24][OH:25])[OH:23]>>[C:10]([C:9]1[C:4]([O:20][CH2:21][CH:22]([OH:23])[CH2:24][OH:25])=[N:5][CH:6]=[C:7]([C:12]2[CH:17]=[CH:16][N+:15]([O-:18])=[CH:14][CH:13]=2)[CH:8]=1)#[N:11]

Participants

5

Reactant 4

HCID 753GlycerolHCID 962WaterHCID 14797Potassium HydroxideHCID 10243008HCID 10243008, compound

Product 1

HCID 19812355HCID 19812355, compound

Procedure

300 mg Potassium hydroxide is dissolved in 15 ml glycerin with heating and 1 g 2-chloro-3-cyano-5,4'-bipyridine-1'-oxide is subsequently added. The reaction mixture is heated for 3 hours at 80° C.-90° C. with stirring, allowed to cool and treated with water. The precipitate obtained is filtered off with suction. Yield: 2 g (89.5% of the theoretical yield), having a melting point of 194° C.-196° C.

Workup

  1. temperaturewith heating
  2. temperatureThe reaction mixture is heated for 3 hours at 80° C.-90° C.
  3. temperatureto cool
  4. customThe precipitate obtained
  5. filtrationis filtered off with suction
  6. customYield: 2 g (89.5% of the theoretical yield),

Sources & evidence

ORD record
ord-24ece2127a334f1c892c4a6341078955
Source dataset
uspto-grants-1992_11
Patent number
US05162533

Reaction notes

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