HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(4-piperidinylmethyl)-1-piperazinyl]-3-quinolinecarboxylic acid monohydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1-Ethyl-6-fluoro-1,4-dihydro-7-[4-[(1-formyl-4-piperidinyl)methyl]-1-piperazinyl]-4-oxo-3-quinolinecarboxylic acid | HCID 19812304 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(4-piperidinylmethyl)-1-piperazinyl]-3-quinolinecarboxylic acid monohydrochloride | HCID 67896255 | 85% |
Reaction Steps
A solution of the N-formylquinolone from Example 18, (1.0 g, 2.25 mmol) in dioxane (20 mL) and aqueous hydrochloric acid (1N, 20 mL) was heated at 100° C. for 31/2 hours. The solvent was removed and the residue was recrystallized from methanol to give the product as a white crystalline solid (0.85 g, 85% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05162523 |
| Source dataset | uspto-grants-1992_11 |
| ORD ID | ord-6e73da833dae4705a0673eb0994987d8 |
| Source note | uspto-grants-1992_11 |