HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[(4-piperidinyl)methyl]-1-piperazinyl]-3-quinolinecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-(4-piperidinylmethyl)-1-piperazinyl]-3-quinolinecarboxylic acid monohydrochloride | HCID 67896255 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[(4-piperidinyl)methyl]-1-piperazinyl]-3-quinolinecarboxylic acid | HCID 19812297 | — |
Reaction Steps
The free base was prepared from the hydrochloride (from Example 19) by dissolving the hydrochloride in water (15 mL/2 g of hydrochloride) and adding saturated aqueous sodium bicarbonate until the pH exceeded 8. After stirring for 15 minutes, the precipitate was collected, washed with water and dried to give the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05162523 |
| Source dataset | uspto-grants-1992_11 |
| ORD ID | ord-34c73ac3b0484944af22607a25078d29 |
| Source note | uspto-grants-1992_11 |