HCID 19810492, compound → HCID 15015034, compound

HRID 373480Notes

Reaction equation

HRID 373480 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][C:2]=1[N:11]1[CH2:14][CH2:13][CH2:12]1.[H][H]>CO.[Pt]=O>[CH2:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH:2]1[N:11]1[CH2:14][CH2:13][CH2:12]1

Participants

5

Reactant 2

HCID 19810492HCID 19810492, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 15015034HCID 15015034, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 887MethanolSolvent

Procedure

The crude product from Step 1 was dissolved in methanol (1 litre) and reduced at room temperature over platinum oxide (5 g) with hydrogen at 120 p.s.i. (about 8.3×105Pa). After 21/2 h, the solution was filtered and evaporated in vacuo. The residue was purified by chromatography (silica; methanol) to give the product (2.5 g as an oil).

Workup

  1. filtrationAfter 21/2 h, the solution was filtered
  2. customevaporated in vacuo
  3. customThe residue was purified by chromatography (silica; methanol)
  4. customto give the product (2.5 g as an oil)

Sources & evidence

ORD record
ord-dc779ce7fcc349f7815f77b40275ee2e
Source dataset
uspto-grants-1992_11
Patent number
US05164385

Reaction notes

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