Hydrochloric Acid → HCID 19810491, compound

HRID 373484Notes

Reaction equation

HRID 373484 reaction equation
[C:1]1([O:7][C:8]2[C:12]([F:14])([F:13])[C:11]([F:16])([F:15])[C:10]([F:18])([F:17])[C:9]=2Cl)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[H][H]>[Pd]>[CH:1]1([O:7][CH:8]2[CH2:9][C:10]([F:17])([F:18])[C:11]([F:15])([F:16])[C:12]2([F:13])[F:14])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 19810490HCID 19810490, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19810491HCID 19810491, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

In a 1.3 l autoclave, 605 g (2 mol) of 2-chloro-3,3,4,4,5,5-hexafluorocyclopentenyl phenyl ether (from Step 1) are suspended in 500 ml of pH 9 buffer (bora/HCl), and the mixture is hydrogenated at 70°-80° C. with 80 bar hydrogen, using 50 g of palladium/charcoal. The catalyst is filtered off, and the filtrate is extracted with dichloromethane. Distillation gives 2,2,3,3,4,4-hexafluorocyclopentyl cyclohexyl ether.

Workup

  1. filtrationThe catalyst is filtered off
  2. extractionthe filtrate is extracted with dichloromethane
  3. distillationDistillation

Sources & evidence

ORD record
ord-9444f4e5bc58434d92216de6b7b09d28
Source dataset
uspto-grants-1992_11
Patent number
US05164383

Reaction notes

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