Acetic Anhydride → HCID 178471888, compound

HRID 373515Notes

Reaction equation

HRID 373515 reaction equation
C([O-])([O-])OCC.C(OC(=O)C)(=O)C.C(O[CH:17]=[C:18]([C:24](=[O:35])[C:25]1[C:30]([F:31])=[CH:29][C:28]([F:32])=[C:27]([F:33])[C:26]=1[F:34])[C:19]([O:21][CH2:22][CH3:23])=[O:20])C.[CH:36]1([NH2:39])[CH2:38][CH2:37]1>>[CH:36]1([NH:39][CH:17]=[C:18]([C:24](=[O:35])[C:25]2[C:30]([F:31])=[CH:29][C:28]([F:32])=[C:27]([F:33])[C:26]=2[F:34])[C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:38][CH2:37]1

Participants

5

Reactant 4

HCID 7918Acetic AnhydrideHCID 69828CyclopropylamineHCID 53630039EthylorthoformateHCID 53702410HCID 53702410, compound

Product 1

HCID 178471888HCID 178471888, compound

Procedure

The resulting compound (28.4 g) was treated with ethyl orthoformate and acetic anhydride to convert it into ethyl 3-ethoxy-2-(2',3',4',6'-tetrafluorobenzoyl)acrylate and this compound was then treated with cyclopropylamine to give 32.8 g of ethyl 3 -cyclopropylamino-2-(2',3',4',6'-tetrafluorobenzoyl)acrylate. m.p. 107°-108° C.

Sources & evidence

ORD record
ord-a5652745488b4d5ca44d3117a14c458c
Source dataset
uspto-grants-1992_11
Patent number
US05164392

Reaction notes

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