Propionyl chloride → HCID 131717641, compound

Participants

Reaction Conditions

Reaction Steps

A quantity of 1.29 g of 1-phenyl-3-methylallyl-barbituric acid prepared as described in Example Ia) is dissolved in 10 ml of pyridine. 0.52 ml of propionyl chloride is added dropwise to this solution which is cooled at 0° C. The reaction mixture is stirred at approximately 0° C. for 30 minutes and then at room temperature for 3 hours, and is then poured on 50 ml of ice water. After stirring with active carbon and filtering, the filtrate is acidified with conc. hydrochloric acid and extracted with methylene chloride. The organic layer is separated, washed with water, dried and evaporated. The final product is purified by means of column chromatography: silica gel/methylene chloride. The title compound is obtained in a yield of 0.65 g; melting-point 76°-80° C.

Provenance & Evidence