HRID373612

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCCCc1nc(CO)c(Cl)n1Cc1ccc(-c2ccccc2-c2nnnn2C(c2ccccc2)(c2ccccc2)c2ccccc2)cc1

HCID22373554

[2-Butyl-5-chloro-1-({2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl][1,1'-biphenyl]-4-yl}methyl)-1H-imidazol-4-yl]methanol

C41H37ClN6O

结构：CCCCc1nc(CO)c(Cl)n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1

HCID131717644

未命名化合物

PRODUCTS

生成物

HCID131717645

未命名化合物

PROCEDURE

实验过程

This Step A compound can be prepared as described in Example 3, Step A, except that 2-butyl-1-[(2'-{N-triphenylmethyltetrazol-5-yl}biphen-4-yl)-methyl]-5-chloro-1H-imidazole-4-methanol (European Patent Applications 253,310 and 291,969) can be used as the starting material for the oxidation instead of 2-butyl-1-[(2'-t-butoxycarbonylbiphen-4-yl)methyl]-5-chloro-1H-imidazole-4-methanol.

WORKUP

后处理

customThis Step A compound can be prepared

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6d69b1225ec240f5b8747c702e23216a
来源数据集: uspto-grants-1992_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05164407
来源说明: uspto-grants-1992_11

反应 SMILES

[CH2:1]([C:5]1[N:6]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[N:30]([C:31]([C:44]4[CH:49]=[CH:48][CH:47]=[CH:46][CH:45]=4)([C:38]4[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=4)[C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:7]([Cl:12])=[C:8]([CH2:10][OH:11])[N:9]=1)[CH2:2][CH2:3][CH3:4].C(C1N(CC2C=CC(C3C=CC=CC=3C(OC(C)(C)C)=O)=CC=2)C(Cl)=C(CO)N=1)CCC>>[CH2:1]([C:5]1[N:6]([CH2:13][C:14]2[CH:15]=[CH:16][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[N:30]([C:31]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)([C:44]4[CH:45]=[CH:46][CH:47]=[CH:48][CH:49]=4)[C:38]4[CH:39]=[CH:40][CH:41]=[CH:42][CH:43]=4)[N:29]=[N:28][N:27]=3)=[CH:18][CH:19]=2)[C:7]([Cl:12])=[C:8]([CH:10]=[O:11])[N:9]=1)[CH2:2][CH2:3][CH3:4]