HCID 13131507, compound → HCID 928691, compound

HRID 373644Notes

Reaction equation

HRID 373644 reaction equation
[NH2:1][C@@H:2]([C:10]([NH:12][CH2:13][C:14]([O:16]C)=O)=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C1(C)C=CC=CC=1>[CH2:3]([C@@H:2]1[C:10](=[O:11])[NH:12][CH2:13][C:14](=[O:16])[NH:1]1)[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

3

Reactant 1

HCID 13131507HCID 13131507, compound

Product 1

HCID 928691HCID 928691, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
0 °C

Procedure

The crude product D-Phe-Gly-OMe (6 g, 25 mmol) was powdered and then dispersed in 100 ml toluene and heated at reflux overnight. The reaction flask was cooled to 0° C. and the solid product (3.50 9, 69%) was collected by filtration: m.p. 256°-257° C.; DCI-NH3 -MS, m/z (relative intensity), 222 (MNH4+, 100%), 205 (MH+, 31%);

Workup

  1. temperatureheated
  2. temperatureat reflux overnight
  3. filtrationthe solid product (3.50 9, 69%) was collected by filtration

Sources & evidence

ORD record
ord-11281c44a8cc4b8c9efeba6f5d979863
Source dataset
uspto-grants-1992_11
Patent number
US05164388

Reaction notes

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