Formaldehyde → HCID 19810960, compound

HRID 373681Notes

Reaction equation

HRID 373681 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([S:7][CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[N:4]=[CH:3]1.[CH2:15]=[O:16]>>[OH:16][CH2:15][C:6]1[N:2]([CH3:1])[CH:3]=[N:4][C:5]=1[S:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Participants

3

Reactant 2

HCID 712FormaldehydeHCID 19810957HCID 19810957, compound

Product 1

HCID 19810960HCID 19810960, compound

Procedure

The 5-carboxyaldehyde-1-methyl-4-(phenylmethyl)thioimidazole intermediate which is a reactant for the above step (a) can be prepared by steps comprising condensing 1-methyl-4-(phenylmethyl)thioimidazole with formaldehyde under weakly acidic conditions to form 5-hydroxymethyl-1-methyl-4-(phenylmethyl)thioimidazole and oxidizing to form said reactant or by directly formylating 1-methyl-4-(phenylmethyl)thioimidazole to form said reactant.

Workup

  1. customcan be prepared by steps

Sources & evidence

ORD record
ord-30d05a043f5747ac9d2f37480bb7831a
Source dataset
uspto-grants-1992_11
Patent number
US05164511

Reaction notes

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