Formaldehyde → HCID 19810960, compound

Participants

Reaction Steps

The 5-carboxyaldehyde-1-methyl-4-(phenylmethyl)thioimidazole intermediate which is a reactant for the above step (a) can be prepared by steps comprising condensing 1-methyl-4-(phenylmethyl)thioimidazole with formaldehyde under weakly acidic conditions to form 5-hydroxymethyl-1-methyl-4-(phenylmethyl)thioimidazole and oxidizing to form said reactant or by directly formylating 1-methyl-4-(phenylmethyl)thioimidazole to form said reactant.

Provenance & Evidence