Hydrochloric Acid → 7-(1-Amino-3-azabicyclo[4.1.0]hept-3-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid, hydrochloride salt

HRID 373707Notes

Reaction equation

HRID 373707 reaction equation
C(OC([NH:8][C:9]12[CH2:15][CH:14]1[CH2:13][CH2:12][N:11]([C:16]1[CH:25]=[C:24]3[C:19]([C:20](=[O:32])[C:21]([C:29]([OH:31])=[O:30])=[CH:22][N:23]3[CH:26]3[CH2:28][CH2:27]3)=[CH:18][C:17]=1[F:33])[CH2:10]2)=O)(C)(C)C.[ClH:34]>>[ClH:34].[NH2:8][C:9]12[CH2:15][CH:14]1[CH2:13][CH2:12][N:11]([C:16]1[CH:25]=[C:24]3[C:19]([C:20](=[O:32])[C:21]([C:29]([OH:31])=[O:30])=[CH:22][N:23]3[CH:26]3[CH2:27][CH2:28]3)=[CH:18][C:17]=1[F:33])[CH2:10]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 20089993HCID 20089993, compound

Product 1

HCID 1317176487-(1-Amino-3-azabicyclo[4.1.0]hept-3-yl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid, hydrochloride saltYield 62%

Procedure

According to the procedure of Example 34B, the compound of Step A (287.2 mg, 0.63 mmol) was converted with hydrochloric acid to provide the title compound, mp 235° C. (152.4 mg, 0.387 mmol, 62% yield).

Sources & evidence

ORD record
ord-ec5717f14496483796cec65db620d10c
Source dataset
uspto-grants-1992_11
Patent number
US05164402

Reaction notes

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