Hydrogen Peroxide → HCID 19808460, compound

HRID 373781Notes

Reaction equation

HRID 373781 reaction equation
[CH2:1]([O:3][C:4]([CH2:6][N:7]1[C:16]2[C:11](=[CH:12][C:13]([Cl:18])=[CH:14][C:15]=2[Cl:17])[N:10]=[CH:9][C:8]1=[O:19])=[O:5])[CH3:2].[OH:20]O.O>C(O)(=O)C>[CH2:1]([O:3][C:4]([CH2:6][N:7]1[C:16]2[C:11](=[CH:12][C:13]([Cl:18])=[CH:14][C:15]=2[Cl:17])[NH:10][C:9](=[O:20])[C:8]1=[O:19])=[O:5])[CH3:2]

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 962WaterHCID 19808448HCID 19808448, compound

Product 1

HCID 19808460HCID 19808460, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The above ester, (70 mg, 0.23 mmol) was reacted with 30% H2O2 (0.345 ml) in glacial acetic acid (0.92 ml) at 55° C. for 4.5 h. The mixture was cooled in an icebath and H2O (0.40 ml) was added. The precipitate was filtered off, washed with water and dried to give 35 mg (48%) of the title compound. 1H-NMR (DMSO-d6):δ1.23 (t, 3H), 4.20 (q, 2H), 5.02 (s, 2H), 7.21 (d, 1H), 7.42 (d, 1H), 12.3 (s, 1H).

Workup

  1. additionwas added
  2. filtrationThe precipitate was filtered off
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-231863cd02c842bc8946945289a82792
Source dataset
uspto-grants-1992_11
Patent number
US05166155

Reaction notes

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