Hydrochloric Acid → 349U85

HRID 373785Notes

Reaction equation

HRID 373785 reaction equation
[N:1]1([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[NH:13][C:12](=[O:17])[CH:11]=[CH:10]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:18]>CO>[ClH:18].[N:1]1([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[NH:13][C:12](=[O:17])[CH:11]=[CH:10]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 164017116942-29-1

Product 1

HCID 164016349U85

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

6-Piperidinocarbostyril, 0.5 g (0.002 mole), was suspended in 15 mL methanol. Five mL ethanolic hydrogen chloride was added, and the mixture was digested in a steam bath for 15 minutes until part of the methanol was evaporated. After cooling, filtration and washing with ethyl acetate, the resulting white crystals, 0.4 g, were recrystallized by dissolving in warm methanol and adding ethyl acetate. The yield was 0.4 g 6-piperidinocarbostyril hydrochloride; m.p. 298°-300° C.

Workup

  1. customwas evaporated
  2. temperatureAfter cooling
  3. filtrationfiltration
  4. washwashing with ethyl acetate
  5. customthe resulting white crystals, 0.4 g, were recrystallized
  6. dissolutionby dissolving in warm methanol
  7. additionadding ethyl acetate

Sources & evidence

ORD record
ord-497c9391f7354888940c6a9df3204ba5
Source dataset
uspto-grants-1992_11
Patent number
US05166160

Reaction notes

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