Dimethylamine → HCID 19808579, compound

HRID 373824Notes

Reaction equation

HRID 373824 reaction equation
[CH3:1][O:2][C:3]1[CH:24]=[CH:23][CH:22]=[C:21](F)[C:4]=1[C:5]([NH:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=1)=[O:9])=[O:6].[CH3:26][NH:27][CH3:28]>CN(C)C=O>[CH3:1][O:2][C:3]1[CH:24]=[CH:23][CH:22]=[C:21]([N:27]([CH3:28])[CH3:26])[C:4]=1[C:5]([NH:7][C:8]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[CH:12]=1)=[O:9])=[O:6]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 19808578HCID 19808578, compound

Product 1

HCID 19808579HCID 19808579, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

1-(2-methoxy-6-fluorobenzoyl)-3-(3-trifluoromethylphenyl)urea is dissolved in an amount of 1.0 g in 6 ml of dimethylformamide. The starting compound is obtained by the method as described in Example VI. Liquified dimethylamine in an amount of 0.5 ml is added and the reaction mixture is heated on 100° C. for 4 hours in a sealed tube. After cooling down to room temperature the reaction mixture is poured on ice-water. The formed precipitate is filtered off and washed with water. The desired compound is obtained in a yield of 0.8 g; melting point 180° C.

Workup

  1. customThe starting compound is obtained by the method
  2. temperatureAfter cooling down to room temperature the reaction mixture
  3. additionis poured on ice-water
  4. filtrationThe formed precipitate is filtered off
  5. washwashed with water

Sources & evidence

ORD record
ord-efc4350190b5421783d7b5cf2adb884c
Source dataset
uspto-grants-1992_11
Patent number
US05166180

Reaction notes

Loading…