HRID3739

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)[C@H](CCCNC(=N)N)NC(=O)c1ccccc1SSc1ccccc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)OC(C)(C)C

HCID178418257

未命名化合物

PRODUCTS

生成物

结构：N=C(N)NCCC[C@H](NC(=O)c1ccccc1SSc1ccccc1C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)C(=O)O

HCID178418317

未命名化合物

收率 59.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID6422

未命名化合物

PROCEDURE

实验过程

This compound was prepared according to the general method of Example 122 using N,N'-[Dithiobis (2,1-phenylenecarbonyl)bis-L-arginine-bis(1,1-dimethylethyl) ester, (1.31 g, 2.0 mmol) from Example 127 in 15 mL of dichloromethane and 15 mL of trifluoroacetic acid. The residue was triturated with ethanol and 1N HCl to yield 0.74 g of the title compound, mp 208°-211° C.;

WORKUP

后处理

customThis compound was prepared
customThe residue was triturated with ethanol and 1N HCl

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d4f02f7260614e1283e973c416bc0d8e
来源数据集: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05734081

反应 SMILES

CC([O:5][C:6](=[O:50])[C@H:7]([CH2:43][CH2:44][CH2:45][NH:46][C:47](=[NH:49])[NH2:48])[NH:8][C:9]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17][S:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]([NH:27][C@H:28]([C:36]([O:38]C(C)(C)C)=[O:37])[CH2:29][CH2:30][CH2:31][NH:32][C:33](=[NH:35])[NH2:34])=[O:26])=[O:10])(C)C>ClCCl.FC(F)(F)C(O)=O>[C:11]1([C:9]([NH:8][C@H:7]([C:6]([OH:50])=[O:5])[CH2:43][CH2:44][CH2:45][NH:46][C:47](=[NH:48])[NH2:49])=[O:10])[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[S:17][S:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=1[C:25]([NH:27][C@H:28]([C:36]([OH:38])=[O:37])[CH2:29][CH2:30][CH2:31][NH:32][C:33](=[NH:34])[NH2:35])=[O:26]