反应详情

Dissolve 2-(carboethoxy)-2-(4-methoxybenzylthio)propane (1.05 g, 3.91 mmol) in a mixture of 95% ethanol (18 mL), water (9 mL) and tetrahydrofuran (10 mL). Add potassium hydroxide (1.4 g, 25 mmol) and stir at room temperature for 2 hours then at 55° C. for 1 hour. Evaporate the solvent in vacuo and partition between water (50 mL) and ether (50 mL). Acidify to pH 1 with concentrated hydrochloric acid and extract into methylene chloride (50 mL). Dry (Na2SO4) and evaporate the solvent in vacuo to give 2-(carboxy)-2-(4-methoxybenzylthio)propane as a tan solid (763 mg).

1. customEvaporate the solvent in vacuo
2. custompartition between water (50 mL) and ether (50 mL)
3. extractionAcidify to pH 1 with concentrated hydrochloric acid and extract into methylene chloride (50 mL)
4. dry with materialDry (Na2SO4)
5. customevaporate the solvent in vacuo