Hydrochloric Acid → HCID 19926590, compound

HRID 373931Notes

Reaction equation

HRID 373931 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[NH:7][C:8]1[CH:13]=[CH:12][C:11](/[CH:14]=[CH:15]/[CH2:16][C:17]([O:19]C)=[O:18])=[CH:10][CH:9]=1.[OH-].[Na+].Cl>O1CCOCC1>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[NH:7][C:8]1[CH:9]=[CH:10][C:11](/[CH:14]=[CH:15]/[CH2:16][C:17]([OH:19])=[O:18])=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86746358HCID 86746358, compound

Product 1

HCID 19926590HCID 19926590, compoundYield 70.3%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

300 mg of methyl (E)-4-{4-((pyrimidin-2yl)amino)phenyl}-3-butenoate was dissolved in 5 ml of dioxane, followed by the addition of 3 ml of a 1N solution of sodium hydroxide. The obtained mixture was stirred at a room temperature for 2 hours, followed by the addition of 3 ml of 1N hydrochloric acid. The crystal thus formed was recovered by filtration and dried under a reduced pressure to obtain 200 mg of the title compound as a white crystal (yield: 70%).

Workup

  1. customThe crystal thus formed
  2. filtrationwas recovered by filtration
  3. customdried under a reduced pressure

Sources & evidence

ORD record
ord-d895cdd9dfe0488cb8ea1bb5493f0f27
Source dataset
uspto-grants-1992_11
Patent number
US05166188

Reaction notes

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