N-Phenylmaleimide → HCID 19808687, 화합물

HRID 373999노트

반응식

HRID 373999 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]([C:11]1[NH:12][C:13]2[C:18]([CH:19]=1)=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH2:10].[C:20]1([N:26]2[C:30](=[O:31])[CH:29]=[CH:28][C:27]2=[O:32])[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>C1(C)C(C)=CC=CC=1>[C:20]1([N:26]2[C:30](=[O:31])[CH:29]3[CH:28]([CH2:10][CH:9]([C:3]4[CH:4]=[CH:5][C:6]([Cl:8])=[CH:7][C:2]=4[Cl:1])[C:11]4[NH:12][C:13]5[C:18]([C:19]=43)=[CH:17][CH:16]=[CH:15][CH:14]=5)[C:27]2=[O:32])[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

참가 물질

4

반응물 2

HCID 13662N-PhenylmaleimideHCID 198087192-[1-(2,4-Dichlorophenyl)vinyl]indole

생성물 1

HCID 19808687HCID 19808687, 화합물수율 50%

시약·촉매·용매 1

HCID 7237O-Xylene용매

실험 절차

7 ml of xylene was added to a mixture of 1.5 g of 2-[1-(2,4-dichlorophenyl)vinyl]indole and 1.0 g of N-phenylmaleimide. The resulting mixture was refluxed for 1 hour. The solvent was removed by distillation under reduced pressure. The residue was recrystallized from isopropyl alcohol to obtain 1.2 g (yield: 50%) of N-phenyl-1-(2,4-dichlorophenyl)-1,2,3,4-tetrahydro-carbazole-3,4-dicarboximide as colorless crystal.

후처리

  1. temperatureThe resulting mixture was refluxed for 1 hour
  2. customThe solvent was removed by distillation under reduced pressure
  3. customThe residue was recrystallized from isopropyl alcohol

출처 및 근거

ORD 기록
ord-0fd4b345d32a4e4f90cdd944df9f8b30
출처 데이터셋
uspto-grants-1992_11
특허 번호
US05166204

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