HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium fluoride → 3'-Fluorothymidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium fluoride | HCID 25516 | — |
| Reactant | 2,3'-Anhydrothymidine | HCID 6915752 | — |
| Reactant | Potassium fluoride, 99%, spray-dried | HCID 53443437 | — |
| Reactant | 3'-Mesylthymidine | HCID 53914209 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | 3'-Fluorothymidine | HCID 33039 | 10% |
Reaction Steps
3'-Mesylthymidine or 2,3'-anhydrothymidine is allowed to react with potassium hydrogen fluoride or ammonium fluoride in ethylene glycol at 191° C. for 10 to 90 minutes, thus giving 3'-deoxy-3'-fluorothymidine (yield: 10 to 14%) [Japanese Patent Publication No. 10472 (1973)].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05166327 |
| Source dataset | uspto-grants-1992_11 |
| ORD ID | ord-1691f48da1a64b31970d925a16ff228d |
| Source note | uspto-grants-1992_11 |