Hydrazine hydrate (1:1) → 8-Ethyl-4-hydrazinyl-7,8-dihydro-2-methyl-6H-pyrimido[5,4-b][1,4]oxazine

HRID 374087Notes

Reaction equation

HRID 374087 reaction equation
Cl[C:2]1[C:7]2[O:8][CH2:9][CH2:10][N:11]([CH2:12][CH3:13])[C:6]=2[N:5]=[C:4]([CH3:14])[N:3]=1.O.[NH2:16][NH2:17]>>[CH2:12]([N:11]1[CH2:10][CH2:9][O:8][C:7]2[C:2]([NH:16][NH2:17])=[N:3][C:4]([CH3:14])=[N:5][C:6]1=2)[CH3:13]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 19909617HCID 19909617, compound

Product 1

HCID 198093818-Ethyl-4-hydrazinyl-7,8-dihydro-2-methyl-6H-pyrimido[5,4-b][1,4]oxazine

Procedure

Using the method of Example 87, 4-chloro-6,7-dihydro-8-ethyl-2-methylpyrimido [5,4-b][1,4]oxazine, from Example 102, was reacted with hydrazine hydrate to provide 6,7-dihydro-8-ethyl-4-hydrazino-2-methylpyrimido[5,4-b][1,4]oxazine.

Sources & evidence

ORD record
ord-71676bdf14914f899b7ffcc91758f526
Source dataset
uspto-grants-1992_11
Patent number
US05166343

Reaction notes

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