Hydrochloric Acid → HCID 136023078, compound

HRID 374090Notes

Reaction equation

HRID 374090 reaction equation
[CH2:1]([C:3]1[NH:4][C:5](=[O:14])[C:6]2[S:11][C:10](=S)[N:9](C)[C:7]=2[N:8]=1)[CH3:2].Cl>[OH-].[Na+]>[CH2:1]([C:3]1[NH:4][C:5](=[O:14])[C:6]([SH:11])=[C:7]([NH:9][CH3:10])[N:8]=1)[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 136149349HCID 136149349, compound

Product 1

HCID 136023078HCID 136023078, compoundYield 85.2%

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Conditions

Temperature
4 °C

Procedure

5-Ethyl-3-methyl-6H-thiazolo[4,5-d]pyrimidin-7-one-2-thione (9.5 g, 41.8 mmole) from Example 108 was suspended in approximately 500 ml of 4N sodium hydroxide solution. The resultant mixture was refluxed for 2 to 4 hours, followed by cooling at approximately 4° C. for about 20 hours. The mixture was slowly acidified with concentrated hydrochloric acid; the solid was separated by filtration and dried, providing 6.6 g (85%) of 2-ethyl-5-mercapto-6-methylamino-3H-pyrimidin-4-one. Infrared and nuclear magnetic resonance spectral analyses confirmed the structural assignment.

Workup

  1. customthe solid was separated by filtration
  2. customdried

Sources & evidence

ORD record
ord-804159a1a56e4fe1ae9bf84104ed836d
Source dataset
uspto-grants-1992_11
Patent number
US05166343

Reaction notes

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