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HRID374124

反应详情

EQUATION

反应方程式

HRID 374124 的结构方程式

REACTANTS

反应物

3
结构：CC1(C)NC(=O)NC1=O
HCID6491

5,5-Dimethylhydantoin

C5H8N2O2

结构：[K+].[OH-]
HCID14797

Potassium hydroxide

HKO

结构：O=[N+]([O-])c1ccc(Cl)cc1C(F)(F)F
HCID67052

5-Chloro-alpha,alpha,alpha-trifluoro-2-nitrotoluene

C7H3ClF3NO2

PRODUCTS

生成物

1
结构：CC1(C)NC(=O)N(c2ccc([N+](=O)[O-])c(C(F)(F)F)c2)C1=O
HCID4493

Nilutamide

C12H10F3N3O4

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CS(C)=O
溶剂HCID679

Dimethyl sulfoxide

C2H6OS

2 次

CONDITIONS

反应条件

温度
110 °C

PROCEDURE

实验过程

30 ml of dimethylsulfoxide and 24.8 grams of 2-nitro-5-chloro trifluoromethylbenzene were introduced at 20° C. with stirring into 100 ml of dimethylsulfoxide, 12.80 grams of 5,5-dimethyl-hydantoin and 6.28 grams of potassium hydroxide in the form of flakes. The mixture was heated to 110° C. for a period of time variable between 3 and 18 hours. The product was characterized and determined by thin layer chromatography.