Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylhydantoin | HCID 6491 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 5-Chloro-2-nitrobenzotrifluoride | HCID 67052 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Nilutamide | HCID 4493 | — |
Reaction Steps
30 ml of dimethylsulfoxide and 24.8 grams of 2-nitro-5-chloro trifluoromethylbenzene were introduced at 20° C. with stirring into 100 ml of dimethylsulfoxide, 12.80 grams of 5,5-dimethyl-hydantoin and 6.28 grams of potassium hydroxide in the form of flakes. The mixture was heated to 110° C. for a period of time variable between 3 and 18 hours. The product was characterized and determined by thin layer chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05166358 |
|---|
| Source dataset | uspto-grants-1992_11 |
|---|
| ORD ID | ord-2ae4db263d7146fbaf6b90c5a74f8452 |
|---|
| Source note | uspto-grants-1992_11 |
|---|
