反应详情

Isopropyl N-cyano-3-pyridinecarboximidate (0.60 g, 3.2 mmol) was dissolved in methanol (10 ml), and 3,3-diphenylpropylamine (0.74 g, 3.5 mmol) was added. The mixture was stirred at room temperature for 1 hour. After the reaction was completed, the reaction solution was concentrated under reduced pressure. The residual concentrate thus obtained was subjected to chromatography on a silica gel column (WAKO GEL C-200, 50 g) eluting with chloroform-methanol (100:1). The eluted fractions were concentrated under reduced pressure and crystallized from methanol-diethyl ether to give the title compound (0.68 g, 2.0 mmol, yield: 63%) as colorless powder.

1. concentrationthe reaction solution was concentrated under reduced pressure
2. concentrationThe residual concentrate thus
3. customobtained
4. washeluting with chloroform-methanol (100:1)
5. concentrationThe eluted fractions were concentrated under reduced pressure
6. customcrystallized from methanol-diethyl ether