HRID374319

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)C[C@H](Cc1ccccc1)C(=O)OCOC(=O)C(C)(C)C)C(=O)OCc1ccccc1

HCID14997137

未命名化合物

PRODUCTS

生成物

结构：CC(C)C[C@H](NC(=O)[C@@H](Cc1ccccc1)C[C@H](Cc1ccccc1)C(=O)OCOC(=O)C(C)(C)C)C(=O)O

HCID14997138

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

0.85 g of N-[4-pivaloyloxymethoxycarbonyl-(R*,R*)-2,4-dibenzylbutyryl]-(L)-leucine benzyl ester in 20 ml of ethanol is hydrogenated at atmospheric pressure in the presence of 0.1 g of 5% palladium on carbon. The reaction is filtered and evaporated to give N-[4-pivaloyloxymethoxycarbonyl-(R*,R*)-2,4-dibenzylbutyryl]-(L)-leucine.

WORKUP

后处理

filtrationThe reaction is filtered
customevaporated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1a7ef3477c6645669ba81a0e001e592c
来源数据集: uspto-grants-1992_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05166212
来源说明: uspto-grants-1992_11

反应 SMILES

C([O:8][C:9](=[O:46])[C@H:10]([CH2:42][CH:43]([CH3:45])[CH3:44])[NH:11][C:12](=[O:41])[C@@H:13]([CH2:34][C:35]1[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=1)[CH2:14][C@@H:15]([C:23]([O:25][CH2:26][O:27][C:28](=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30])=[O:24])[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)C1C=CC=CC=1>C(O)C.[Pd]>[C:28]([O:27][CH2:26][O:25][C:23]([C@@H:15]([CH2:16][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=1)[CH2:14][C@H:13]([CH2:34][C:35]1[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=1)[C:12]([NH:11][C@H:10]([C:9]([OH:46])=[O:8])[CH2:42][CH:43]([CH3:44])[CH3:45])=[O:41])=[O:24])(=[O:33])[C:29]([CH3:30])([CH3:31])[CH3:32]