反应详情

The aqueous phases from Example 2 (87.4 g) and Example 3 (854.4 g), after decomposition of the 1-(3-methoxyphenyl)ethylammonium salts with hydrochloric acid and extraction with hexane, were combined and mixed with 94 g of 25 percent sodium hydroxide solution. The pure amine was extracted three times with 100 ml each of dichloromethane. After distilling off the solvent and vacuum distillation of the residue, 62.1 g of (R)-(+)-1-(3-methoxyphenyl)-ethylamine [content (GC) : 100%, [α]D20 : 22.0° (c=10, methanol)] was obtained as a colorless liquid.

1. extractionThe pure amine was extracted three times with 100 ml each of dichloromethane
2. distillationAfter distilling off
3. distillationthe solvent and vacuum distillation of the residue