ethyl p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoate → p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoic acid

HRID 37439Notes

Reaction equation

HRID 37439 reaction equation
[CH3:1][C:2]1([CH3:26])[C:7]2[CH:8]=[CH:9][C:10]([C:12]([NH:14][C:15]3[CH:25]=[CH:24][C:18]([C:19]([O:21]CC)=[O:20])=[CH:17][CH:16]=3)=[O:13])=[CH:11][C:6]=2[S:5][CH2:4][CH2:3]1.[OH-].[K+].C(O)C.O>>[CH3:1][C:2]1([CH3:26])[C:7]2[CH:8]=[CH:9][C:10]([C:12]([NH:14][C:15]3[CH:25]=[CH:24][C:18]([C:19]([OH:21])=[O:20])=[CH:17][CH:16]=3)=[O:13])=[CH:11][C:6]=2[S:5][CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 19935413ethyl p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoateHCID 23714421Potassium hydroxide ethanol water

Product 1

HCID 18990063p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoic acid

Procedure

Hydrolysis of the foregoing ester with potassium hydroxide/ethanol/water in analogy to Example 57 gave p-(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-7-carboxamido)benzoic acid, melting point 274°-276° C.

Sources & evidence

ORD record
ord-ee93df0709024f47a9424441cd4335d9
Source dataset
uspto-grants-1995_05
Patent number
US05420273

Reaction notes

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