HCID 19698834, compound → HCID 19698823, compound

HRID 374435Notes

Reaction equation

HRID 374435 reaction equation
[CH3:1][N:2]1[C:6](C(O)=O)=[C:5]([C:10]([OH:12])=[O:11])[N:4]=[C:3]1[NH:13][CH:14]([CH3:16])[CH3:15]>CN(C)C(=O)C>[CH3:1][N:2]1[CH:6]=[C:5]([C:10]([OH:12])=[O:11])[N:4]=[C:3]1[NH:13][CH:14]([CH3:16])[CH3:15]

Participants

3

Reactant 1

HCID 19698834HCID 19698834, compound

Product 1

HCID 19698823HCID 19698823, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Conditions

Temperature
180 °C

Procedure

A mixture of 1-methyl-2-isopropylamino-4,5-dicarboxyimidazole (910 mg; 4 mmol) and 20 ml of N,N-dimethylacetamide is heated at 180° C. under argon for three hours. The solvent is evaporated under reduced pressure; the residue, taken up with minimum ethanol, is precipitated with tetrahydrofuran. The mother liquors are concentrated until precipitation is obtained. The 1-methyl-2-isopropylamino-4-carboxyimidazole is obtained with a yield of 88%.

Workup

  1. customThe solvent is evaporated under reduced pressure
  2. customis precipitated with tetrahydrofuran
  3. concentrationThe mother liquors are concentrated until precipitation
  4. customis obtained

Sources & evidence

ORD record
ord-3e4e243b35f54964a60d9e2ae079ba6f
Source dataset
uspto-grants-1996_01
Patent number
US05480884

Reaction notes

Loading…