HCID 131719234, compound → HCID 131719235, compound

HRID 374437Notes

Reaction equation

HRID 374437 reaction equation
[NH2:1][C:2]1[NH:3][C:4](=[O:16])[C:5]([C:8]([OH:15])([CH:12]([OH:14])[CH3:13])[C:9]([OH:11])=[O:10])(O)[N:6]=1>C(O)C>[NH2:1][C:2]1[N:6]=[C:5]([C:8]([OH:15])([CH:12]([OH:14])[CH3:13])[C:9]([OH:11])=[O:10])[C:4](=[O:16])[N:3]=1

Participants

3

Reactant 1

HCID 131719234HCID 131719234, compound

Product 1

HCID 131719235HCID 131719235, compoundYield 22%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2 g of the crude compound of Example 18 (8.23 mmol), solubilized in 80 ml of anhydrous ethanol, is refluxed for one hour. After evaporation and purification on silica gel (eluent: 35% MeOH/5% H2O/CH2Cl2 then 40% MeOH/5% H2O/CH2Cl2) 400 mg are obtained with a yield of 22%.

Workup

  1. temperatureis refluxed for one hour
  2. customAfter evaporation and purification on silica gel (eluent
  3. custom35% MeOH/5% H2O/CH2Cl2 then 40% MeOH/5% H2O/CH2Cl2) 400 mg are obtained with a yield of 22%

Sources & evidence

ORD record
ord-ce11621bc76449b489bd76617c543be8
Source dataset
uspto-grants-1996_01
Patent number
US05480884

Reaction notes

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