反应详情

A solution of the product from (1) in ethanol:water (300 ml:300 ml) containing 5% aqueous sodium hydroxide (2 ml) was treated with ethanolamine (17 ml) and then refluxed for 18 hours with rapid stirring. The resultant solution was cooled and adjusted to pH 1 with concentrated hydrochloric acid. The solid which formed on cooling was extracted with hot absolute ethanol and the precipitate obtained on cooling was taken up in diethylether, the solution being filtered and evaporated to dryness by rotary evaporation to give the title compound in 44.94% yield, m.p. 191.5°-193° C.

1. temperaturerefluxed for 18 hours with rapid stirring
2. customThe solid which formed
3. temperatureon cooling
4. extractionwas extracted with hot absolute ethanol
5. customthe precipitate obtained
6. temperatureon cooling
7. filtrationthe solution being filtered
8. customevaporated to dryness by rotary evaporation