Acetic Acid → HCID 15281826, compound

HRID 374497Notes

Reaction equation

HRID 374497 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH:11]([CH2:13][O:14][C:15]3[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=3)[O:10][C:9]2=[O:25])=[CH:4][CH:3]=1.[C:26](O)(=[O:28])[CH3:27]>>[C:26]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:12][CH:11]([CH2:13][O:14][C:15]3[CH:24]=[CH:23][C:18]([C:19]([O:21][CH3:22])=[O:20])=[CH:17][CH:16]=3)[O:10][C:9]2=[O:25])=[CH:4][CH:3]=1)(=[O:28])[CH3:27]

Participants

3

Reactant 2

HCID 176Acetic Acid2×HCID 15281825HCID 15281825, compound

Product 1

HCID 15281826HCID 15281826, compoundYield 99%

Procedure

A 1.2 ml quantity of anhydrous acetic acid was added dropwise to an acetic acid (60 ml) solution of 3.0 g of methyl 4-[3-(4-aminophenyl)-2-oxooxazolidin-5-yl]methoxybenzoate obtained in Example 9 at room temperature, and the mixture was stirred at the same temperature for 1 hour. The crystals were collected by filtration and washed with ethanol to give 3.05 g of the title compound (compound 113) in a yield of 99%.

Workup

  1. filtrationThe crystals were collected by filtration
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-141cabd3e8464d939d06a2bc9083bd9c
Source dataset
uspto-grants-1996_01
Patent number
US05480899

Reaction notes

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