2-Nitroimidazole → HCID 11020015, compound

HRID 374586Notes

Reaction equation

HRID 374586 reaction equation
[N+:1]([C:4]1[NH:5][CH:6]=[CH:7][N:8]=1)([O-:3])=[O:2].C(=O)([O-])[O-].[K+].[K+].[CH2:15]([C@@H:17]1[O:19][CH2:18]1)[Cl:16]>>[Cl:16][CH2:15][C@H:17]([OH:19])[CH2:18][N:5]1[CH:6]=[CH:7][N:8]=[C:4]1[N+:1]([O-:3])=[O:2]

Participants

4

Reactant 3

HCID 107012-NitroimidazoleHCID 11430Potassium CarbonateHCID 2734062(-)-Epichlorohydrin

Product 1

HCID 11020015HCID 11020015, compound

Procedure

Alternatively, a mixture of 0.42 g (3.7 mmole) of 2-nitroimidazole, 85 mg (0.62 mole) of anhydrous potassium carbonate, and 5 mL of (R)-(-)-epichlorohydrin is refluxed for 10 minutes then filtered while hot. The filtrate is concentrated and cooled to give a solid. Crystallization from ethanol and further processing as above gives 0.56 g of the product.

Workup

  1. temperatureis refluxed for 10 minutes
  2. filtrationthen filtered while hot
  3. concentrationThe filtrate is concentrated
  4. temperaturecooled
  5. customto give a solid
  6. customCrystallization from ethanol and further processing as

Sources & evidence

ORD record
ord-4345f8e20f2f4d4da573bbf41597bd7b
Source dataset
uspto-grants-1996_01
Patent number
US05481000

Reaction notes

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